比利时布鲁塞尔自由大学ProfPat

TheLaboratoryofSoftMatterPhysicsoftheUniversitéLibredeBruxelles(ULB)inBelgiumissearchingforhighlymotivatedcandidateswithexcellentacademicrecordstoperformaPhDinthetopic“Formationofbiomimeticmembranelayersonnanostructuredsurfaces:Fundamentalsandapplications”.TheselectedPhDcandidateshouldapplyforfundstotheChinaScholarshipCouncil(CSC)withintheframeworkoftheULB-CSCagreementtosupport30PhDsperyear.

Shortdescriptionoftheproject:

Increasingdemandsonimplantdevicesmakethenextgenerationofimplantablematerialsfeaturethecapacitytoprovidesustainedelutionofgrowthfactorsand/orantibioticstofurthersupportboneregenerationand/orcounteractbacterialcolonization.Nano/Mesoporousmetalsdisplayalargesurfaceareaandhaverecentlyattractedsignificantinterestduetopotentialapplicationsincatalysisorenergyharvestingandstorage.Theirlargesurfaceareaandhighly-tunableproperties,aspromisingmaterialscandidatesforbiotechnologyapplicationsmakethemidealplatformsforbiosensorswithenhancedsensitivityandtheirdrugcapacityabilitywithintheirporousinteriormakesthemtemplatesforsustaineddrugrelease.Integratingnp-metalswithstimuli-responsivesoftmatter(lipids,polymersystems)canbeapointofdeparturetodevelopnovelbiosensingplatformsanddetection-drugdeliverysystems.Yet,therearemanyopenandpracticallyunexploredfundamentalquestionsregardingtheirformation,surfacefunctionalizationandfunctioningmechanisms.

Theaimofthisprojectistofabricate,functionalizenanoporousmetals,i.e.,nanoporousgold(np-Au)andnanoporoustitaniumandevaluatethecapabilityofnp-Auandnp-Tiasbiosensorplatformscontrolleddrugreleaseplatforms.Goldhasmanydesirableattributes,includinghighelectricalconductivitytodetectelectrophysiologicalsignalsandtunablemorphology.Titaniumisbio

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